Faculty
Faculty
Qing-Jian Han
Professor
Principal Investigator
Dr. Qingjian Han received his Ph.D. degree in Cell Biology from Shanghai Institute of Biochemistry and Cell Biology, CAS in 2013. From 2013 to 2018, he obtained the postdoctoral training at Duke University Medical Center in USA. Dr. Han joined the Institutes of Brain Science, Fudan University as principal investigator Since Jan. 2019. The work was published on several important journals in neuroscience including Neuron, Trends Neurosci, Cell Discov, Plos Biol.
Contact Information
Address: Research Building No. 2, 131 Dongan Road, Institutes of Brain Science, Fudan University, ShanghaChina 200032
Tel：021-54237585
Email：qingjianhan@@fudan.edu.cn
Research Directions
Mechanisms of pain and analgesic strategies
Pain constitutes a complicated integration of somatic perception and emotional experience. Persistent chronic pain drastically deteriorates patients’ life quality and triggers neuropsychiatric disorders including anxiety and depression. Our lab constructs a variety of chronic pain mouse models and employs a suite of approaches covering behavioral testing, electrophysiological recording, opto- and chemo-genetic manipulation, as well as viral neural tracing. We aim to systematically unravel the molecular substrates and circuit mechanisms driving pain chronification, and translate these basic findings into innovative analgesic interventions.
Enrollment Major
Neurobiology
Selected Publications
Tong F#, Zhou J#, Chen Z#, Tang X, Gu X, Wang W, Yang H, Hu P*, Wang Z*, Han Q*(2026). Primary somatosensory neuron-derived Zn2+ orchestrates muscle regeneration via Hippo signaling pathway.Cell Discov. 12(1):47
Zhang S#, Dong FY#, Cai S#, Zhou B#, Jiang L#, Hu LP#, Zhu YH, Li H, Yang XM, Cai Z, Yao LL, Wang H, Yao HF, Li J, Li Q, Zhu L, Yang Q, Liu LM, Yu YQ, Zhang JF, Hua R, Zhang XL, Zhu HH, Niu N, Xue J, Jiang C, Sun YW, Han Q*, Li DX*, Liu DJ*, Zhang ZG*, Jiang SH*(2026). A peritumoral microenvironment engaged by Reg-EXTL3 axis fosters nerve-cancer interactions in pancreatic ductal adenocarcinoma. Neuron. doi: 10.1016/j.neuron.2026.03.039
Liu S, Long SS, Li F, Yang H, Pu S, Du D, Luo X, Zhang YQ, Han Q*(2025). Neural basis of transcutaneous electrical nerve stimulation for neuropathic pain relief. Neuron. 113(21):3616-3631
Tong F#, Liu S#, Zhang C#, Gu X, Yang H, Zhou B, Wang YY, Chen J, Qu Q, Gong Y, Pan H, Liang C, Li C, Zhang X*, Han Q*(2024). Elevated vesicular Zn2+ in dorsal root ganglion neurons expressing the transporter TMEM163 causes age-associated itchy skin in mice.PLoS Biol. 22(11):e3002888
Zhang C#, Tong F#, Zhou B#, He M, Liu S, Zhou X, Ma Q, Feng T, Du WJ, Yang H, Xu H, Xiao L, Xu ZZ, Zhu C, Wu R*, Wang YQ*, Han Q*(2024). TMC6 functions as a GPCR-like receptor to sense noxious heat via Gαq signaling. Cell Discov. 10(1):66
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