Faculty
Faculty
Zhi-Xiang Xu
Professor
Principal Investigator
Welcome to my lab! I got my bachelor’s degree in Tongji medical college, Huazhong University of Science and Technology, afterward I continued my graduate training with Professor Fuqiang Xu at WIPM, CAS. After getting my Ph.D. degree I worked as a research associate in the Neuroscience department, Scripps Florida. I start my own lab at the Institutes of Brain Science, Fudan University since 2020. I published a serial of papers including Nature Communications(2)， Cell Reports(2), Advanced Science, JCI insight, Neurobiology of Disease et al.
Contact Information
Address: 138 Yixueyuan Road, Institutes of Brain Science, Fudan University, Shanghai China 200032
Email：zhixiangxu@@fudan.edu.cn
Research Direction
Functions of microglia under physiological and pathological conditions;
Neuroimmune mechanism in the pathogenesis of autism spectrum disorders
Enrollment Major
Neurobiology
Research Work
The Xu Laboratory at the Institutes of Brain Science, Fudan University employs integrated neuroscience approaches to study neuroimmune system function in the brain, in particularly how microglia modulate neuronal activity and brain circuit formation during brain development and disease conditions. We employ techniques including molecular biology, mouse behavior tests, electrophysiology, RNA-seq to illuminate the fundamental mechanisms of neuroimmune biology. Knowledge resulting from these research programs will present new avenues for treatments of neurodevelopmental and neurodegeneration disorders.
Selected Publications
Xie TX, Xiang JK, He Y, Tian M*, Zhan W, Hua LY, Deng SX, Pan R, Gao YL, Chen M, Hu RFK, Gong Y*, Xu ZX* (2025). An excitatory circuit in the ventrolateral periaqueductal gray drives hypometabolic state during acute systemic inflammation. Cell Rep. 44(10):116394
Sheng LH#*, Gao JP#, Wei QY, Gong Y*, Xu ZX*(2025). The glial UDP-glycosyltransferase Ugt35b regulates longevity by maintaining lipid homeostasis in Drosophila. Cell Rep. 44(1): 115099
Shi ZY, Mao LL, Chen SN, Du ZY, Xiang JK, Shi MH, Wang YN, Wang YQ, Chen XD, Xu ZX*, Gao YQ*(2024). Reversing Persistent PTEN Activation after Traumatic Brain Injury Fuels Long-Term Axonal Regeneration via Akt/mTORC1 Signaling Cascade. Adv Sci. 16:e2410136
Xu ZX, Kim GH, Tan JW, Riso AE, Sun Y, Xu EY, Liao GY, Xu HF, Lee SH, Do NY, Lee CH, Clipperton-Allen AE, Kwon S, Page DT, Lee KJ, Xu BJ* (2020). Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations. Nat Commun. 11(1):1797
Xu ZX, Tan JW, Xu HF, Hill CJ, Ostrovskaya O, Martemyanow KA, Xu BJ* (2019). Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling. Nat Commun. 10(1):3622
Online Appointment
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