Faculty
Faculty
Zhong-Feng Wang
Professor
Principal Investigator
Zhongfeng Wang, Ph.D., currently serves as Principal Investigator (PI), Tenured Professor, and Doctoral Supervisor at the Institute of Brain Science, Fudan University. He obtained his Ph.D. degree from Chongqing Medical University in 1997. He completed postdoctoral research at the Institute of Physiology, Chinese Academy of Sciences (June 1998 – February 2001) and previously served as Associate Professor at the Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. From August 2003 to October 2007, he was a visiting scholar in the Department of Physiology at Northwestern University, USA. He joined Fudan University in October 2007. His honors include one Second Prize of the Shanghai Natural Science Award (2006) and one Third Prize of the Shanghai Science and Technology Progress Award (2001); one Second Prize of the Military Science and Technology Progress Award (1997); the Wang Kuancheng Postdoctoral Research Award Fund of the Chinese Academy of Sciences; the Zhang Xijun Foundation Outstanding Paper Award of the China Society of Physiology; the Shanghai-Unilever Research and Development Fund Scholarship; and the Meiji Dairy Life Science Excellence Award. He has led nine general projects funded by the National Natural Science Foundation of China, participated as a key researcher in one major and one key project of the National Natural Science Foundation, and four sub-projects under the 973 Program; led two key basic research projects in Shanghai and contributed to one major project. In 2008, he received Category A funding under the Shanghai Pujiang Talent Program. He has published over 90 research papers in domestic and international professional journals, more than 80 of which have been indexed by SCI, including Neuron, Nature Neuroscience, Progress in Retinal and Eye Research, Advanced Science, TINS, Journal of Neuroscience, Journal of Neuroinflammation, Biomaterials, and EBioMedicine.
Contact Information
Address: Room B5-006, Scientific Research Building 2, Institute of Brain Science, Fudan University, No. 131 Dong'an Road, Shanghai
Tel：86-21-5423-7810 (office)
Email：zfwang@@fudan.edu.cn
Research Directions
Neuronal visual damage and regeneration
Enrollment Major
Neurobiology
Research Work
Professor Zhongfeng Wang's primary research focuses on neuronal visual damage and regeneration. Utilizing patch-clamp electrophysiology and pharmacology, combined with techniques from morphology and molecular biology, he investigates the mechanisms of neuronal injury in neurodegenerative retinal diseases (such as glaucoma and diabetic retinopathy), as well as the role of interactions between glial cells and neurons in neuronal damage and regeneration.
Selected Publications
Zhao GL#,*, Li Z#, Zhao MJ, Li SY, Xia Q, Xu SY, Zhang Y, Wang Y, Li F, Liu YL, Guo YH, Xu RX, Zhou H, Zhou H, Ding WW, Wang YC, Miao YY*, Wang ZF*(2025). A High-Fidelity RNA-Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma. Adv Sci. 12: e15856
Gao SX#, Li Q#, Zhang SH, Sun XH, Zhou H*, Wang ZF*, Wu JH*(2023). A novel biosensing platform for detection of glaucoma biomarker GDF15 via an integrated BLI-ELASA strategy. Biomaterials. 294: 121997
Miao YY#,, Zhao GL#, Cheng S, Wang ZF*, Yang XL*(2023). Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma. Prog Retin Eye Res. 93: 101169
Hu X#, Zhao GL#, Xu MX, Zhou H, Li F, Miao YY, Lei B, Yang XL*, Wang ZF*(2021). Interplay between Müller cells and microglia aggravates retinal inflammatory response in experimental glaucoma. J Neuroinflamm. 18(1): 303
Cheng S, Wang HN, Xu LJ, Li F, Miao YY, Lei B, Sun XH*, Wang ZF*(2021). Soluble tumor necrosis factor-alpha-induced hyperexcitability contributes to retinal ganglion cell apoptosis by enhancing Nav1.6 in experimental glaucoma. J Neuroinflamm. 18(1): 182
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