Faculty
Faculty
Man Xiong
Researcher
Principal Investigator
Dr Man Xiong received her PhD. from Children's Hospital of Fudan University in 2013. From 2013 to 2016, She worked as a postdoc. in the Department of Neuroscience and Neurology at University of Wisconsin-Madison. Since 2016, she worked as an associate professor and professor in Children’s hospital, Fudan University. Her work has been published on Cell Stem Cell (2015, 2016, 2021), Cell Reports (2021), iScience (2020, 2022), Journal of Clinical Investigation (2022), Brain (2023), and Stem Cell Res Ther. (2024). In January 2022, Dr. Xiong joined Institutes of Brain Science at Fudan University as a principal investigator.
Contact Information
Address: Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Email：man_xiong@@fudan.edu.cn
Research Directions
Human pluripotent stem cell differentiation and stem cell therapy for brain disorder, pathogenesis of developmental encephalopathy
Most neurological diseases are characterized by irreversible damage and loss of multiple neural cells. Human pluripotent stem cells (hPSCs) provide a model to study early neural development, model pathological processes, and develop therapeutics. Transplanted hPSCs-derived neuronal cells into diseased brain not only replace the function of lost cells by repairing the damaged neural networks, but also restore brain function. Besides, hPSC-derived three-dimensional brain organoid was also used for disease modeling, pathogenesis and precise drug screening. Our group will focus on developing new protocols to differentiate specific neural types or subtypes, which combined with stem cell gene-editing, lineage tracing, optogenetics/chemical genetics and electrophysiology to study circuit mechanisms of cell therapy for important brain disorders such as, hypoxic-ischemic brain injury and stroke. Besides, we will study pathogenesis and potential drug target of important developmental brain disorders in children using induced pluripotent stem cells from patient and genetic mouse model.
Enrollment Major
Neurobiology
Selected Publications
Mei Y#, Xu Y#, Zhang X#, Feng B, Zhou Y, Cheng Q, Li Y, Peng X, Wu M, Xiao L, Zhou W, Chen Y*, Xiong M*(2025). 3D-cultured human medium spiny neurons functionally integrate and rescue motor deficits in Huntington's disease mice. J Clin Invest. In Press
Yan W#, Gao Q#, Zhou Y, Xu P, Wu Z, Yuan T, Xie L, You Z, Zhang X, Feng B, Yang S, Chen Y*, Xiong M*(2025). Human stem cell-derived A10 dopaminergic neurons specifically integrate into mouse circuits and improve depression-like behaviors. Cell Stem Cell. doi: 10.1016/j.stem.2025.07.007
Wu M#, Xu Y#, Ji X, Zhou Y, Li Y, Feng B, Cheng Q, He H, Peng X, Zhou W, Chen Y, Xiong M*(2024). Transplanted deep-layer cortical neuroblasts integrate into host neural circuits and alleviate motor defects in hypoxic-ischemic encephalopathy injured mice. Stem Cell Res Ther. 15(1): 422
Ji X#, Zhou Y#, Gao Q, He H, Wu Z, Feng B, Mei Y, Cheng Y, Zhou W*, Chen Y*, Xiong M*(2023). Functional reconstruction of the basal ganglia neural circuit by human striatal neurons in hypoxic-ischaemic injured brain. Brain. 146(2): 612-628
Dong X#, Yang L#, Liu K, Ji X, Tang C, Li W, Ma L, Mei Y, Peng T, Feng B, Wu Z, Tang Q, Gao Y, Yan K, Zhou W*, Xiong M*(2025). Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment. Cell Rep. 34(9):108802
Online Appointment
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