Faculty
Prof. Wen-Ying Fan

Prof. Wen-Ying Fan



Research Direction
Mechanisms of brain injury and remodeling after stroke; Blood-brain barrier dysfunction and vascular cognitive impairment

Contact Information
Address: State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China

Email: wenyingf@fudan.edu.cn

Dr. Fan received her Ph.D. degree in Medicine from Hamamatsu University School of Medicine in Japan in 2002. She did postdoctoral research at Boston University School of Medicine in USA for three years. She joined the State Key Laboratory of Medical Neurobiology and Institute of Brain Science at Fudan University in 2010. Her research focuses on the mechanisms of brain injury and remodeling after stroke, especially on the blood-brain barrier/neurovascular unit remodeling. Her research results have been published in prominent international journals such as Blood, PNAS, Nat Common, PLOS Biol, Stroke and Stem Cells.

 

Enrollment Major
Neurobiology

  

Selected Publications

1. Wang R, Zhu Y, Liu Z, Chang L, Bai X, Kang L, Cao Y, Yang X, Yu H, Shi MJ, Hu Y, Fan W*, Zhao BQ* (2021). Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. Blood. 138: 91-103
2. Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, Cao Y, Xu H, Luo H, Lu L, Shi MJ, Tian Y, Fan W*, Zhao BQ* (2020). Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun. 11: 2488
3. Cao Y, Xu H, Zhu Y, Shi MJ, Wei L, Zhang J, Cheng S, Shi Y, Tong H, Kang L, Lu L, Luo H, Yang X, Bai X, Wang R, Ma Y, Wang Y, Wang Z, Zhong K*, Zhao BQ*, Fan W* (2019). ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology. PLOS Biol. 17: e3000313
4. Xu H, Cao Y, Yang X, Cai P, Kang L, Zhu X, Luo H, Lu L, Wei L, Bai X, Zhu Y, Zhao BQ, Fan W* (2017). ADAMTS13 controls vascular remodeling by modifying VWF reactivity during stroke recovery. Blood. 130: 11-22
5. Cai P, Luo H, Xu H, Zhu X, Xu W, Dai Y, Xiao J, Cao Y, Zhao Y, Zhao BQ*, Fan W* (2015). Recombinant ADAMTS 13 attenuates brain injury after intracerebral hemorrhage. Stroke. 46: 2647-53


138 Yixueyuan Road, Shanghai 200032, China; Tel:021-54237641   

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