Prof. Wen-Ying Fan
Mechanisms of brain injury and remodeling after stroke; Blood-brain barrier dysfunction and vascular cognitive impairment
Address: State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Dr. Fan received her Ph.D. degree from Hamamatsu University School of Medicine in Japan. She did postdoctoral research at Boston University School of Medicine in USA. She joined the State Key Laboratory of Medical Neurobiology and Institute of Brain Science at Fudan University in 2010. Her research focuses on the mechanisms of brain injury and remodeling after stroke, especially on the blood-brain barrier and neurovascular unit remodeling.
1. Wang R, Zhu Y, Liu Z, Chang L, Bai X, Kang L, Cao Y, Yang X, Yu H, Shi MJ, Hu Y, Fan W*, Zhao BQ* (2021). Neutrophil extracellular traps promote tPA-induced brain hemorrhage via cGAS in mice with stroke. Blood. 138: 91-103
2. Kang L, Yu H, Yang X, Zhu Y, Bai X, Wang R, Cao Y, Xu H, Luo H, Lu L, Shi MJ, Tian Y, Fan W*, Zhao BQ* (2020). Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke. Nat Commun. 11: 2488
3. Cai P, Luo H, Xu H, Zhu X, Xu W, Dai Y, Xiao J, Cao Y, Zhao Y, Zhao BQ*, Fan W* (2015). Recombinant ADAMTS 13 attenuates brain injury after intracerebral hemorrhage. Stroke. 46: 2647-53
4. Fan W*, Dai Y, Xu H, Zhu X, Cai P, Wang L, Sun C, Hu C, Zheng P, Zhao BQ* (2014). Caspase-3 modulates regenerative response after stroke. Stem Cells. 32:473-86