Prof. Xian-Hua Chen
Research Directions
Regulation of gene function in neurodegenerative diseases and cerebral ischemia
Contact Information
Address: 131 Dongan Road, Institutes of Brain Science, Fudan University, Shanghai China 200032
Tel:021-54237094 Email: xhchen@fudan.edu.cn
Dr. Xianhua Chen received her B.S. degree in Biophysics in 1990 and her PhD degree in Physiology & Biophysics in 2003 from Fudan University. She entered the State Key Laboratory of Medical Neurobiology from 2006 as an associate professor and is currently a full professor. Her research interest is the regulation of gene function in neurodegenerative diseases and cerebral ischemia, with a focus on the neuronal-protective function and the underlying mechanism of the up-regulated expressed genes in astrocytes and oligodendrocyte lineage cells after cerebral ischemia and in the pathogenesis of neurodegenerative diseases. She has published a number of research papers in the peer-reviewed international journals such as J Neurosci, Glia, J Biol Chem, iScience, etc.
Enrollment Major
Neurobiology
Selected Publications
1. Li J, Jiang H, Mu Y, Wei Z, Ma A, Sun M, Zhao J, Zhu C, Chen XH* (2023). SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex. iScience. 26(7):107042.
2. Jiang Y, Li JJ, Mu YW, Jiang HY, Wei ZX, Xiao ZY, Zhao JJ, Chen XH*(2022). Overexpression of Cpg15 Alleviates the Oxidative Stress in Neuronal Cells Via Regulating Redox Enzymes and Nrf2 Antioxidative Pathway. Neurotox Res. 40:365–372.
3. Li CJ，Li JJ，Jiang Y，Mu YW, Lu DX, Xiao ZY, Jiang HY, Zhao JJ, Chen XH*(2020). Decreased cpg15 augments oxidative stress in sleep deprived mouse brain. Biochem Biophys Res Commun. 522: 749-756.
4. Zhao JJ, Hu JX, Lu DX, Ji CX, Qi Y, Liu XY, Sun FY, Huang F, Xu P, Chen XH*（2017）. Soluble cpg15 from astrocytes ameliorates neurites outgrowth recovery of hippocampal neurons after mouse cerebral ischemia. J Neurosci. 37:1628–1647.
5. Qi Y, Li Y, Cui SC, Zhao JJ, Liu XY, Ji CX, Sun FY, Xu P, Chen XH*（2015）. Splicing factor NSSR1 reduces neuronal injury after mouse transient global cerebral ischemia. Glia. 63: 826–845.
