Prof. Xian-Hua Chen

Research Directions
Regulation of gene function in neurodegenerative diseases and cerebral ischemia 
Contact  Information
Address: Room B5-015, Research Building No. 2, 138 Yixueyuan Road, Institutes of Brain Science, Fudan University, Shanghai China, 200032 
Tel:021-54237094 Email: xhchen@fudan.edu.cn

Dr. Xianhua Chen received her B.S. degree in Biophysics in 1990 and her PhD degree in Physiology & Biophysics in 2003 from Fudan University. She entered the State Key Laboratory of Medical Neurobiology from 2006 as an associate professor and is currently a full professor. Her research interest is the regulation of gene function in neurodegenerative diseases and cerebral ischemia, with a focus on the neuronal-protective function and the underlying mechanism of the up-regulated expressed genes in astrocytes after cerebral ischemia and in the pathogenesis of Alzheimer’s disease. She has published a number of research papers in the peer-reviewed international journals such as J Neurosci, Glia, J Biol Chem, J Neurotraum, etc. 

Enrollment Major
Neurobiology

Selected Publications

1. Zhao JJ, Hu JX, Lu DX, Ji CX, Qi Y, Liu XY, Sun FY, Huang F, Xu P, Chen XH*（2017）. Soluble cpg15 from astrocytes ameliorates neurites outgrowth recovery of hippocampal neurons after mouse cerebral ischemia. J Neurosci. 37:1628-1647

2. Qi Y, Li Y, Cui SC, Zhao JJ, Liu XY, Ji CX, Sun FY, Xu P, Chen XH*（2015）. Splicing factor NSSR1 reduces neuronal injury after mouse transient global cerebral ischemia. Glia. 63: 826-845

3. Liu XY, Li HL, Su JB, Ding FH，Zhao JJ, Chai F, Li YX, Cui SC, Sun FY, Wu ZY, Xu P, Chen XH*（2015）. Regulation of RAGE splicing by hnRNP A1 and Tra2β-1 and its potential role in AD pathogenesis. J Neurochem. 133:187-198.

4. Li SJ, Qi Y, Zhao JJ, Li Y, Liu XY, Chen XH*, Xu P*（2013）. Characterization of Nuclear Localization Signals (NLSs) and Function of NLSs and Phosphorylation of Serine Residues in Subcellular and Subnuclear Localization of Transformer-2β (Tra2β). J Biol Chem. 288: 8898-909

5. Li SJ, Li Y, Cui SC, Qi Y, Zhao JJ, Liu XY, Xu P, Chen XH*（2013）. Splicing Factor Transformer-2β (Tra2β) Regulates the Expression of Regulator of G Protein Signaling 4 (RGS4) Gene and Is Induced by Morphine. PLoS One. 8: e72220