Prof. Qing-Jian Han
Principal Investigator
Research Directions
The neuronal mechanisms and neural circuities of pain and itch
Contact Information
Address: Room B5014, Research Building No. 2, 131 Dongan Road, Institutes of Brain Science, Fudan University, Shanghai China 200032
Tel：021-54237585 Email: qingjianhan@fudan.edu.cn
Dr. Qingjian Han received his Ph.D. degree in Cell Biology from Shanghai Institute of Biochemistry and Cell Biology, CAS in 2013. From 2013 to 2018, he obtained the postdoctoral training at Duke University Medical Center in USA. Dr. Han joined the Institutes of Brain Science (IOBS), Fudan University as principal investigator Since Jan. 2019. The work was published on several important journals in neuroscience including Neuron, J Clin Invest, Cell Discov, Environ Int, Br J Pharmacol, Neurosci Bull.
Enrollment Major
Neurobiology
Research Direction
Pain and itch Pain are two complex subjective sensations and emotional experiences. Persistent pain and itch not only severely impact patients' quality of life but also lead to central nervous system disorders such as anxiety and depression. Our research is based on various pain and itch mouse models and combines behavioral studies, electrophysiology, histology, molecular biology, optogenetics, and viral tracing techniques to investigate the molecular mechanisms and neural circuits underlying pain and itch formation, as well as the functions and mechanisms of physical stimuli like transcutaneous electrical nerve stimulation(TENS) in pain relief and other neurological disorders.
Selected Publications
1. Zhang C, Tong F, Zhou B, He M, Liu S, Zhou X, Ma Q, Feng T, Du W, Yang H, Xu H, Xiao L, Xu Z, Zhu C, Wu R*, Wang Y*, Han Q*(2024). TMC6 Functions as a GPCR-like Receptor to Sense 1 Noxious Heat Via Gαq Signaling. Cell Discov. 10: 66. (*Corresponding author)
2. Guo J, Lei L, Yang H, Zhou B, Fan D, Wu B, Wang G, Yu L, Zhang C, Zhang W, Han Q*, Zhang XY*, Zhao J*(2024). Effects of nasal allergens and environmental particulate matter on brainstem metabolites and the consequence of brain-spleen axis in allergic rhinitis. Environ Int. 190: 108890. (*Corresponding author)
3. Chen O#, He Q#, Han Q#, Furutani K, Gu Y, Olexa M, Ji RR*(2023). Mechanisms and treatments of neuropathic itch in a mouse model of lymphoma. J Clin Invest. 133(4):e160807. (#Co-first author)
4. Han Q#, Di Liu#, Convertino M, Wang Z, Jiang C, Kim YH, Luo X, Zhang X, Nackley A, Dokholyan NV, Ji RR*(2018). miRNA-711 binds and activates TRPA1 extracellularly to evoke acute and chronic pruritus. Neuron. 99:449-463 (#Co-first author)
5. Han Q#, Kim YH#, Wang X#, Liu D, Zhang ZJ, Bey AL, Lay M, Chang W, Berta T, Zhang Y, Jiang YH, Ji RR*(2016). SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons. Neuron. 92: 1279-1293. (#Co-first author)
