Prof. Yu Gu

Principal Investigator

Research Direction
Functional circuit for visuo-motor transition and treatment for amblyopia

Contact Information
Address: 131 Dong An Road, Research Building B, Room CB1-047, Fudan University, Shanghai China 200032 

Tel: 021-54237183  Email: guyu_@fudan.edu.cn

Dr. Yu Gu graduated from Tsinghua University with a B.S. degree in biology in 2007 and from the University of Maryland with a Ph.D. degree in neuroscience in 2014. From 2014 to 2017, he conducted postdoctoral research in the Department of Neurobiology at Northwestern University in America, and joined the Institutes of Brain Science at Fudan University in 2018. His research results have been published in Nature Neuroscience, Neuron, eLife, Journal of Neuroscience and many other well-known journals in the field of neuroscience. He has been supported by 3 National Natural Science Foundation of China and was entitled as Shanghai Science Commission Rising-Star and Young Oriental Scholar in Shanghai. Currently, he is also a committee member of the Sensory and Motor Branch of the Chinese Society of Neuroscience and a young editorial board member of the journal Neuroscience Bulletin.

Enrollment Major
Neurobiology

Research Work
The visuo-motor transition is an important component of the brain's ability to integrate sensory inputs and respond behaviorally, and is important for the survival of the organism. Its circuital functions mainly include visual integration, multisensory coordination, decision making and behavior initiation. Amblyopia is a common visual disorder during visual development, mainly caused by visual input deficits, which can result in severe impairment of visuo-motor transition and other visual functions. We use experimental techniques such as in vivo multichannel electrophysiology and whole-brain calcium imaging to investigate the regulatory mechanism of the visuo-motor transition circuit and provide methods for the treatment of amblyopia and improvement of visual function.

Selected Publications

1. Li CQ#, Sun TP#, Zhang YM#, Gao Y, Sun Z, Li W, Cheng HP, Gu Y*, Abumaria N*(2023). A neural circuit for regulating a behavioral switch in response to prolonged uncontrollability in mice. Neuron. doi: 10.1016/j.neuron.2023.05.023

2. Li N, Liu Q, Zhang YM, Yang ZY, Shi XF*, Gu Y*(2022). Article Cortical feedback modulates distinct critical period development in mouse visual thalamus. iScience. 26(1): 105752

3. Chan JP, Hao XW, Liu Q, Cang JH, Gu Y*(2021). Closing the Critical Period Is Required for the Maturation of Binocular Integration in Mouse Primary Visual Cortex. Front Cell Neurosci. 15: 749265

4. Hao XW, Gu Y*(2020). New progress on binocular disparity in higher visual areas beyond V1. Neurosci Bull. 36(10):1236-1238

5. Gu Y, Cang JH*(2016). Binocular matching of thalamocortical and intracortical circuits in the mouse visual cortex. eLife. 5:e22032