Prof. Ming Chen
Neural mechanism of reward and aversion
Address: Room B5-027, Research Building No. 2, 138 Yixueyuan Road, Institutes of Brain Science, Fudan University, Shanghai China, 200032
Dr. Ming Chen received his M.D. degree from Shandong First Medical University (Taishan Medical College) in 2009 and Ph.D. degree from the State Key Laboratory of Medical Neurobiology of Fudan University in 2012. From 2012 to 2016, he was a postdoctoral fellow in the Institute of Brain Science at Fudan University. He worked at the school of life science and technology of ShanghaiTech University from 2017 to 2022. He joined the Institute of Brain Science in October 2022. His work was published on several important journals in neuroscience including Neuron, eLife, Science Advances, BMC Biology, Addition Biology.
Reward and aversion, as animal instinctive behaviors, are closely related to the occurrence of neuropsychiatric diseases. We develop and apply cutting-edge methods, by electrophysiology, optical imaging, neuromodulation, circuit tracings and 3D animal behavior to functional dissect the neural mechanisms of reward or aversion and associated neuropsychiatric diseases. Our study will contribute to the understanding and treatment of several devastating psychiatric disorders, such as drug addiction, depression and anxiety.
1. Su XY#, Chen M#, Yuan Y, Li Y, Guo SS, Luo HQ, Huang C, Sun W, Li Y, Zhu MX, Liu MG*, Hu J*, Xu TL*(2019). Central Processing of Itch in the Midbrain Reward Center. Neuron. 102(4):858-872
2. Song JJ, Shao D, Guo XL, Zhao YF, Cui DY, Ma QQ, Sheng H, Ma L, Lai B*, Chen M*, Zheng P*(2019). Crucial role of feedback signals from prelimbic cortex to basolateral amygdala in the retrieval of morphine withdrawal memory. Sci Adv. 5(2): eaat3210
3. Zhao YF#, Zhang JF, # Yang HL#, Cui DY, Song JJ, Ma QQ, Luan WJ, Lai B, Ma L, Chen M*, Zheng P*(2017). Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala. BMC Biol. 15:128
4. Yuan KJ#, Sheng H#, Song JJ#, Yang L, Cui DY, Ma QQ, Zhang W, Lai B, Chen M*, Zheng P*(2017). Morphine treatment enhances glutamatergic input onto neurons of the nucleus accumbens via both disinhibitory and stimulating effect. Addict Biol. 22(6): 1756-1767
5. Chen M, Zhao Y, Yang H, Luan W, Song J, Cui D, Dong Y, Lai B, Ma L, Zheng P* (2015). Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation. eLife. 4: e09275