Prof. Xian-Hua Chen
Research Directions
Regulation of gene function in neurodegenerative diseases and cerebral ischemia
Contact Information
Address:State Key Laboratory of Medical Neurobiology, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Tel: +86-21-54237094 Email: xhchen@fudan.edu.cn
Dr. Xianhua Chen received her B.S. degree in Biophysics in 1990 and her PhD degree in Physiology & Biophysics in 2003 from Fudan University. She entered the State Key Laboratory of Medical Neurobiology from 2006 as an associate professor and is currently a full professor. Her research interest is the regulation of gene function in neurodegenerative diseases and cerebral ischemia, with a focus on the neuronal-protective function and the underlying mechanism of the up-regulated expressed genes in astrocytes after cerebral ischemia and in the pathogenesis of Alzheimer’s disease. She has published a number of research papers in the peer-reviewed international journals such as J Neurosci, Glia, J Biol Chem, J Neurotraum, etc.
Enrollment Major
Neurobiology
Research Direction
Regulation of gene function in neurodegenerative diseases and cerebral ischemia
Selected Publications
Zhao JJ, Hu JX, Lu DX, Ji CX, Qi Y, Liu XY, Sun FY, Huang F, Xu P, Chen XH*（2017）. Soluble cpg15 from astrocytes ameliorates neurites outgrowth recovery of hippocampal neurons after mouse cerebral ischemia. J Neurosci, 37:1628-1647
Qi Y, Li Y, Cui SC, Zhao JJ, Liu XY, Ji CX, Sun FY, Xu P, Chen XH*（2015）. Splicing factor NSSR1 reduces neuronal injury after mouse transient global cerebral ischemia. Glia. 63: 826-845
Liu XY, Li HL, Su JB, Ding FH，Zhao JJ, Chai F, Li YX, Cui SC, Sun FY, Wu ZY, Xu P, Chen XH*（2015）. Regulation of RAGE splicing by hnRNP A1 and Tra2β-1 and its potential role in AD pathogenesis. J Neurochem. 133:187-198.
Li SJ, Qi Y, Zhao JJ, Li Y, Liu XY, Chen XH*, Xu P*（2013）. Characterization of Nuclear Localization Signals (NLSs) and Function of NLSs and Phosphorylation of Serine Residues in Subcellular and Subnuclear Localization of Transformer-2β (Tra2β). J Biol Chem. 288: 8898-909
Li SJ, Li Y, Cui SC, Qi Y, Zhao JJ, Liu XY, Xu P, Chen XH*（2013）. Splicing Factor Transformer-2β (Tra2β) Regulates the Expression of Regulator of G Protein Signaling 4 (RGS4) Gene and Is Induced by Morphine. PLoS One. 8: e72220
