Prof. Man Xiong
Human pluripotent stem cell differentiation and stem cell therapy for brain disorder, pathogenesis of developmental encephalopathy
Address: Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Dr Man Xiong received her MD PhD in Pediatrics from Children’s hospital Fudan University in 2013，From 2013 to 2016, She worked as a postdoc. in the Department of Neuroscience and Neurology at University of Wisconsin-Madison. Since 2016, she worked as an associate professor and professor in Children’s hospital, Fudan University. Her work has been published on Cell Stem Cell (2015, 2016, 2021), Cell reports and iScience. In December of 2021, Dr. Xiong joined Institutes of Brain Science at Fudan University as a principal investigator.
Most neurological diseases are characterized by irreversible damage and loss of multiple neural cells. Human pluripotent stem cells (hPSCs) provide a model to study early neural development, model pathological processes, and develop therapeutics. Transplanted hPSCs-derived neuronal cells into diseased brain not only replace the function of lost cells by repairing the damaged neural networks, but also restore brain function. Besides, hPSC-derived three-dimensional brain organoid was also used for disease modeling, pathogenesis and precise drug screening. Our group will focus on developing new protocols to differentiate specific neural types or subtypes, which combined with stem cell gene-editing, lineage tracing, optogenetics/chemical genetics and electrophysiology to study circuit mechanisms of cell therapy for important brain disorders such as, hypoxic-ischemic brain injury and stroke. Besides, we will study pathogenesis and potential drug target of important developmental brain disorders in children using induced pluripotent stem cells from patient and genetic mouse model.
1. Ji X#, Zhou Y#, Gao Q, He H, Wu Z, Feng B, Mei Y, Cheng Y, Zhou W*, Chen Y*, Xiong M*(2022). Functional reconstruction of the basal ganglia neural circuit by human striatal neurons in hypoxic-ischaemic injured brain. Brain. 15: awac358.
2. Ma L#, Mei Y#, Xu P, Cheng Y, You Z, Ji X, Zhuang D, Zhou W, Chen Y, Xiong M*(2022). Fast generation of forebrain oligodendrocyte spheroids from human embryonic stem cells by transcription factors. iScience. 25(10):105172.
3. Dong X#, Yang L#, Liu K, Ji X, Tang C, Li W, Ma L, Mei Y, Peng T, Feng B, Wu Z, Tang Q, Gao Y, Yan K, Zhou W*, Xiong M*(2021). Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment. Cell Reports. 34(9):108802.
4. Xiong M#, Tao Y#, Gao Q, Feng B, Yan W, Zhou Y, Kotsonis TA, Yuan T, You Z, Wu Z, Xi J, Haberman A, Graham J, Block J, Zhou W, Chen Y*, Zhang SC(2021). Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function. Cell Stem Cell. 28(1):112-126.