Prof. Yi-Zheng Wang

Member of Chinese Academy of Sciences

Research Directions
Neural Regulation and Neurological Disorders
Contact  Information
Address: Research Building No. 2,138 Yixueyuan Road, Institutes of Brain Science, Fudan University, Shanghai China 200032
Tel：021-54237795（office）  Email: yzwang@ion.ac.cn

Dr. Yizheng Wang earned his Ph.D. from Laval University, Canada, in 1991 and pursued postdoctoral research at Case Western Reserve University, the United States, from 1991 to 1994. Since January 2022, he has been affiliated with Huashan Hospital, Fudan University, and concurrently serves as a Principal Investigator at the State Key Laboratory of Medical Neurobiology and the MOE Frontiers Center for Brain Science (within the Institutes of Brain Science, Fudan University).

His research focuses on neurological disorders. Over the years, he has conducted extensive investigations in neurobiology, systematically examining how ion channels and ion homeostasis modulate neuronal survival and development, as well as their pathological implications for neurological diseases. His work has elucidated the calcium sources underlying neurotrophic factor–regulated neuronal survival, neural development, and plasticity. Notably, he has also revealed the critical role of TRPC6 in ischemic brain injury and Aβ amyloid formation.

Enrollment Major
Neurobiology

Selected Publications

1. Gao Y, Gao D, Zhang H, Zheng D, Du J, Yuan C, Ma M, Yin Y, Wang J, Zhang X, Wang Y*(2024). BLA DBS improves anxiety and fear by correcting weakened synaptic transmission from BLA to adBNST and CeL in a mouse model of foot shock. Cell Rep. 43(8):114575

2. Wang Y, Du J, Lu S, Li X, Chen Y, Yuan C, Hou ST*, Wang Y*(2022). PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice.Signal Transduct Target Ther. 7(1):82

3. Wang Y, Lu S, Chen Y, Li L, Li X, Qu Z, Huang J, Fan L, Yuan C, Song N, Zhang J, Xu W, Yang S, Wang Y*(2021). Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke. Sci Transl Med. 13(610):eaba3444

4. Zhang H, Zhang C, Qu Z, Li B, Su Y, Li X, Gao Y, Wang Y*(2021). STN-ANT plasticity is crucial for the motor control in Parkinson's disease model. Signal Transduct Target Ther. 6(1):215

5. Wang J, Lu R, Yang J, Li H, He Z, Jing N, Wang X, Wang Y*(2015). TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production. Nat Commun. 6:8876