Prof. Yi-Zheng Wang

Member of Chinese Academy of Sciences

Research Directions
Neural Regulation and Neurological Disorders
Contact  Information
Address: Floor 3, Building B, Medical Research Building, 131 Dong'an Road, Xuhui District, Shanghai
Tel：021-54237795（office）  Email: yzwang@ion.ac.cn

Dr. Yizheng Wang obtained his Ph.D. degree in Laval University in Canada in 1991, and conducted postdoctoral research at Case Western Reserve University in the United States from 1991 to 1994.He was introduced to Huashan Hospital affiliated to Fudan University in January 2022 and was concurrently appointed to State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University,as a principal investigator .

His research has focused on neurological disorders. He has been engaged in long-term research in the field of neurobiology, systematically studying the mechanisms by which ion channels and ion homeostasis affect the survival and development of neurons, as well as their pathological significance in neurological disorders. He has provided insights into the calcium sources involved in neurotrophic factor-regulated neuronal survival, neural development, and plasticity. Additionally, he has made significant contributions to understanding the important role of TRPC6 in ischemic brain injury and Aβamyloid formation.

Enrollment Major
Neurobiology

Selected Publications

1. Wang Y, Du J, Lu S, Li X, Chen Y, Yuan C, Hou ST*, Wang Y*(2022). PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice. Signal Transduct Target Ther. 7(1):82

2. Wang Y, Lu S, Chen Y, Li L, Li X, Qu Z, Huang J, Fan L, Yuan C, Song N, Zhang J, Xu W, Yang S, Wang Y*(2021). Smoothened is a therapeutic target for reducing glutamate toxicity in ischemic stroke. Sci Transl Med. 13(610):eaba3444

3. Zhang H, Zhang C, Qu Z, Li B, Su Y, Li X, Gao Y, Wang Y*(2021). STN-ANT plasticity is crucial for the motor control in Parkinson's disease model. Signal Transduct Target Ther. 6(1):215

4. Wang J, Lu R, Yang J, Li H, He Z, Jing N, Wang X, Wang Y*(2015). TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production.Nat Commun. 6:8876

5. Li Y, Jia YC, Cui K, Li N, Zheng ZY, Wang YZ*, Yuan XB*(2005). Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor.Nature. 434(7035):894-8