Prof. Lan Ma

Member of Chinese Academy of Sciences

Director of Institutes of Brain Science

Research Directions
Intracellular signal transduction and molecular mechanisms of drug addiction
 

Dr. Lan Ma received her B.S. degree in Pharmacy from Shenyang College of Pharmacy in 1982 and M.S. degree in Immunology from China Medical University in 1984. She obtained her Ph.D. degree in Biological Chemistry in 1990 and postdoctoral training thereafter from the Department of Chemistry at the University of North Carolina at Chapel Hill. Upon completion of her second postdoctoral fellowship at Bayer Corporation in 1995, Dr. Ma returned to China and joined the faculty of Shanghai Medical University (presently Fudan University Medical Center) as a full professor and the State Key Laboratory of Medical Neurobiology as a principal investigator. Her research has focused on the molecular mechanisms of drug addiction and signal transduction of G-protein coupled receptors ever since. She has authored more than 80 papers in prominent international journals and received many awards for her achievements in research and teaching. Dr. Ma is currently a Senior Principal Investigator and the Director of Institutes of Brain Science, Fudan University. She also serves as Vice President of the Chinese Association for Physiological Sciences and on the editorial boards of the Journal of Biological Chemistry, Neuropharmacology, and other peer-reviewed international journals.

Enrollment Major
Pharmacology

Research Direction

Intracellular signal transduction and molecular mechanisms of drug addiction

 
Research Work

1. Intracellular Signal Transduction

2. Molecular Mechanisms of Drug Addiction

Selected Publications

1. Jiang C, Wang X, Le Q, Liu P, Liu C, Wang Z, He G, Zheng P, Wang F*, Ma L*(2019). Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward. Mol Psychiatry. doi: 10.1038/s41380-019-0480-7

2. Le Q, Yan B, Yu X, Li Y, Song H, Zhu H, Hou W, Ma D, Wu F, Zhou Y, Ma L*(2017). Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour. Nat  Commun. 8: 15527

3. Liu X, Ma L, Li HH, Huang B, Li YX, Tao YZ, Ma L* (2015) . β-arrestin-biased signaling mediates memory reconsolidation. Proc Natl Acad Sci USA. 112: 4483-4488

4. Chen YJ, Wang F, Long H, Chen Y, Wu Z, Ma L* (2011). GRK5 promotes F-actin bundling and targets bundles to membrane structures to control neuronal morphogenesis. J Cell Biol. 194: 905-920

5. Wang L, Lv Z, Hu Z, Sheng J, Hui B, Sun J, Ma L* (2010). Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKII in the nucleus accumbens is critical for motivation for drug reinforcement. Neuropsychopharmacology. 35: 913-928