Faculty
Prof. Yun-Li Xie

Prof. Yun-Li Xie


Principal Investigator

Research Directions
Neural stem cell and brain development
Contact  Information
Address: Room 1002, Mingdao Building, Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Tel: 86-021-54237317  Email: yunli.xie@fudan.edu.cn

Dr. Yunli Xie received his PhD in neuroscience from Tuebingen University, Germany 2008. Followed a postdoctoral training at IMBA-Institute for Molecular Biotechnology, Austria Academy of Science, he joined Fudan University at IOBS since 2014 as a principle investigator.

 

Research Direction
Neural stem cell and brain development

Understanding how neural stem cells maintain their proliferative capacity and how their progenies differentiate into distinct lineages is of fundamental importance, not only for understanding brain development, but also for understanding the pathogenesis of neurodevelopmental disorders, the initiation of brain tumors, and the therapeutic potential of brain disorders. My long-term goal is to determine how neural stem cells balance between symmetric and asymmetric divisions, and how misregulation of the mechanisms that control neural stem cell divisions lead to abnormal brain development and neurological disorders.


Select1ed Publications

1. Wang Y, Lu Z, Zhang Y, Cai Y, Yun D, Tang T, Cai Z, Wang C, Zhang Y, Fang F, Yang Z, Behnisch T, Xie Y* (2019). Transcription Factor 4 Safeguards Hippocampal Dentate Gyrus Development by Regulating Neural Progenitor Migration. Cereb Cortex, doi: 10.1093/cercor/bhz297

2. Tang T, Zhang Y, Wang Y, Cai Z, Lu Z, Li L, Huang R, Hagelkruys A, Matthias P, Zhang H, Seiser C ,Xie Y*(2019). HDAC1 and HDAC2 regulate intermediate progenitor positioning to safeguard neocortical development. Neuron, doi:10.1016/j.neuron.2019.01.007

3. Xie Y, Juschke C, Esk C, Hirotsune S, Knoblich JA* (2013). The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex. Neuron, 79: 254-265

4. Juschke C, Xie Y, Postiglione MP, Knoblich JA*(2014) . Analysis and modeling of mitotic spindle orientations in three dimensions. Proc Natl Acad Sci U S A, 111: 1014-1019

5. Xie Y, Vessey JP, Konecna A, Dahm R, Macchi P*, Kiebler MA* (2007) . The dendritic spine-associated GTP-binding protein Septin 7 is critical for dendrite branching and dendritic spine morphology. Curr Biol, 17: 1746-1751

138 Yixueyuan Road, Shanghai 200032, China; Tel:021-54237641   

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