Prof. T. Behnisch
1. Search for cellular mechanisms underlying memory formation
2. Methodical approaches include combined electrophysiological and optical measurements as well as fluorogenic determination of enzyme activities
Address: Room 1110, Mingdao Building, Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Tel：86-21-54237590 Fax：86-21-54237643 Email：firstname.lastname@example.org
Thomas Behnisch, neuroscientist, graduated from department of physiology, National University Kazan, 1988 and awarded a Ph. D. degree by the Institute of Biochemistry, Freie University Berlin, Germany. He worked in the Leibniz Institute for Neurobiology, Magdeburg, Germany, from 1994 to 2007. In this time, he also contributed to the ongoing research of the Lab for Neuronal Circuit Dynamics, BSI-Riken, Japan as a visiting scientist. Since 2007, he became a principal investigator of the Institutes of Brain Science and State Key Laboratory of Medical Neurobiology at the Fudan University, Shanghai, China P.R.
Past research work was focused on cellular mechanisms underlying memory formation, emphasizing the role of phospholipase C signaling cascade (PLC), metabotropic glutamate receptors, protein kinase C, inositol phosphates and intracellular calcium stores in mechanisms of hippocampal activity-dependent synaptic plasticity (LTP). More recently he is investigating the contribution of activity-dependent protein synthesis as well as ubiquitin proteasome dependent protein degradation in hippocampal synaptic plasticity using real time monitoring of fluorescent protein turn-over in neurons.
Huang Y, Chen J, Chen Y, Zhuang Y, Sun M* and Behnisch T* (2015). The neurotoxin 1-methyl-4-phenylpyridinium(MPP+) alters hippocampal excitatory synaptic transmission by modulation of the GABAergic system. Front Cell Neurosci,4 ;9 :299.
Hong X, Liu J, Zhu G, Zhuang Y, Suo H, Wang P, Huang D, Xu J, Huang Y, Yu M, Bian M, Sheng Z, Fei J, Song H, Behnisch T*, Huang F* (2014).Parkin overexpression ameliorates hippocampal long-term potentiation and β-amyloid load in an Alzheimer‘s disease mouse model. Hum Mol Genet,23(4):1056-72.
Mikhaylova M, Karpova A, Bar J, Bethge P, Yuanxiang P, Chen Y, Zuschratter W, Behnisch T, Kreutz MR (2013).Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger protein Jacob in the rat brain. Brain Struct Funct, 219(3):843-6.
Karpova A, Mikhaylova M, Bera S, Bar J, Reddy PP, Behnisch T , Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Zuschratter W, Kähne T, Naumann M,Gundelfinger ED, Kreutz MR. (2013). Encoding and Transducing the Synaptic or Extrasynaptic Origin of NMDA Receptor Signals to the Nucleus. Cell, 1119-1133.
GuoQi Zhu, YuQing Huang, Ying Chen, YingHan Zhuang and Behnisch T* (2012). MPTP modulates hippocampal synaptic transmission and activity-dependent synaptic plasticity via dopamine receptors. J Neurochem, 122:582-593.