Prof. T. Behnisch

Principal Investigator

Research Direction
1. Search for cellular mechanisms underlying memory formation
2. Methodical approaches include combined electrophysiological and optical measurements as well as fluorogenic determination of enzyme activities
Contact Information
Address: B4025, Scientific Research Building 2, Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Tel：86-21-54237590  Fax：86-21-54237643  Email：behnish@fudan.edu.cn

Thomas Behnisch, neuroscientist, graduated from department of physiology, National University Kazan, 1988 and awarded a Ph. D. degree by the Institute of Biochemistry, Freie University Berlin, Germany. He worked in the Leibniz Institute for Neurobiology, Magdeburg, Germany, from 1994 to 2007. In this time, he also contributed to the ongoing research of the Lab for Neuronal Circuit Dynamics, BSI-Riken, Japan as a visiting scientist. Since 2007, he became a principal investigator of the Institutes of Brain Science and State Key Laboratory of Medical Neurobiology at the Fudan University, Shanghai, China P.R.

Enrollment Major
Neurobiology

Research Work

Past research work was focused on cellular mechanisms underlying memory formation, emphasizing the role of phospholipase C signaling cascade (PLC), metabotropic glutamate receptors, protein kinase C, inositol phosphates and intracellular calcium stores in mechanisms of hippocampal activity-dependent synaptic plasticity (LTP). More recently he is investigating the contribution of activity-dependent protein synthesis as well as ubiquitin proteasome dependent protein degradation in hippocampal synaptic plasticity using real time monitoring of fluorescent protein turn-over in neurons.

Selected Publications

1. Wang CJ, Pan YC, Zhang WW, Chen Y, Li CH, Zhao F, Behnisch T*(2021). Positive Regulatory Domain I-binding Factor 1 Mediates Peripheral Nerve Injury-induced Nociception in Mice by Repressing Kv4.3 Channel Expression. Anesthesiology. 134(3): 435-456

2. Liu ZY, Peng C, Zhuang YH, Chen Y, Behnisch T*(2020). Direct medial entorhinal cortex input to hippocampal CA3 is crucial for eEF2K inhibitor-induced neuronal oscillations in the mouse hippocampus. Front Cell Neurosci. 14: 24

3. Li DX, Jing DQ, Liu ZY, Chen Y, Huang F*, Behnisch T*(2019). Enhanced expression of secreted alpha-klotho in the hippocampus alters nesting behavior and memory formation in mice. Front Cell Neurosci. 13: 133

4. Pang KKL, Sharma M, Krishna-K K, Behnisch T*, Sajikumar S*(2019). Long-term population spike-timing-dependent plasticity promotes synaptic tagging but not cross-tagging in rat hippocampal area CA1S. P Natl Acad Sci USA. 116(12): 5737-5746

5. Yun D, Zhuang YH, Kreutz MR, Behnisch T*(2018). The role of 19S proteasome associated deubiquitinases in activity-dependent hippocampal synaptic plasticity. Neuropharmacology. 133: 354-365