Prof. Zhong-Feng Wang
Principal Investigator
Research Directions
Retinal function and synaptic plasticity
Contact Information
Address: Room 1101, Mingdao Building, Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Tel：: 86-21-5423-7810 (office) Email: zfwang@fudan.edu.cn
Dr. Zhongfeng Wang graduated from Chongqing Medical University and received his Ph.D. and M. D. degrees in 1997. From Jun 1998 to Feb 2001, he got his postdoctoral training in Shanghai Institute of Physiology, Chinese Academy of Sciences (CAS), and then he was appointed as an associate professor in Shanghai Institutes for Biological Sciences, CAS. From Aug 2003 to Oct 2007, he worked as a research associate in the Department of Physiology at Northwestern University, Chicago, USA. He joined in the Institute of Brain Science, Fudan University in 2007.
Dr. Wang is a full-time professor and principal investigator in IOBS, Institute of Neurobiology and State Key Laboratory of Medical Neurobiology at the Fudan University. He is a member of Society for Neuroscience, USA, Chinese Association for Physiological Sciences, and Chinese Society for Neuroscience. He has won a number of awards including Shanghai Natural Science Award, the Leica Neuroscience Awards, Life Science Awards of Meiji Dairies, Shanghai-Unilever Research & Development Awards, Scientific and Technological Research Awards of Shanghai and Excellent Academic Article of Chinese Association for Physiological Sciences, etc. He has been inviting as a member of editorial board in Acta Physiologica Sinica since 2002. His professional achievements are best represented by over 50 peer-reviewed papers, over 30 published in prestigious SCI-cited journals including Nature Neuroscience, Neuron and TINS, etc.
Enrollment Major
Neurobiology
Research Direction
Retinal function and synaptic plasticity
Research Work
Information transmission and processing are unique functions of nervous system. To explore the underlying mechanism is one of the major issues in neuroscience. As an important component of central nerve system, retina is one of the best models for studying the information processing of brain because the retina consists of several cell types and the cells are simply arranged. Research in Dr. Wang’s lab focuses on retinal synaptic transmission and its underlying mechanisms by using patch-clamp techniques, pharmacological method, combing with immunohistochemistry, Western blot and molecular biology. The current researches in Dr. Wang’s lab include two aspects.
1. Retinal synaptic transmission and plasticity
2. Glaucoma
Selected Publications
Dong LD, Gao F, Wang XH, Miao Y, Wang SY, Wu Y, Li F, Wu J, Cheng XL, Sun XH, Yang XL, Wang Z* (2015). GluA2 trafficking is involved in apoptosis of retinal ganglion cells induced by activation of EphB/EphrinB reverse signaling in a rat chronic ocular hypertension model. J Neurosci, 35: 5409-5421.
Ji M, Miao Y, Dong LD, Chen J, Mo XF, Jiang SX, Sun XH*, Yang XL, Wang Z* (2012). Group I mGluR-mediated inhibition of Kir channels contributes to retinal Müller cell gliosis in a rat chronic ocular hypertension model. J Neurosci ,32: 12744-12755.
Wang XH,Wu Y,Yang XF, Miao Y, Zhang CQ, Dong LD, Yang XL, Wang Z* (2016). Cannabinoid CB1 receptor signaling dichotomously modulates inhibitory and excitatory synaptic transmission in rat inner retina. Brain Struct Funct, 221: 301-316.
Chen J, Miao Y, Wang XH, Wang Z* (2011). Elevation of p-NR2AS1232 by Cdk5/p35 contributes to retinal ganglion cell apoptosis in a rat experimental glaucoma model. Neurobiol Dis, 43: 455-464.
Zhao WJ, Zhang M, Miao Y, Yang XL*, Wang Z* (2010). Melatonin potentiates glycine currents through distinct PC-PLC/PKC signaling pathway in rat retinal ganglion cells. J Physiol (Lond) ,588: 2605-2619.
