Prof. Yue Li
How monoamine modulate synaptic plasticity and control behavior
Address: Institute of Brain Science, Fudan University, 131 Dongan Road, Shanghai, China, 200032
Dr. Yue Li obtained her PhD degree from Zhejiang University in 2019. She worked at University of Geneva as a postdoctoral researcher from 2018 to 2022. Her previous work focused on drug addiction and synaptic plasticity. Since December of 2022, she has been working at Fudan University as a principle investigator.
Drugs targeting the monoamine system are attracting a broad interest since they have a potential to treat neuropsychiatric disorders. However their clinical use are limited due to their neural stimulate effects and abuse risks. Our lab focus on investigating the mechanisms of how these drugs affect the neural system, aiming to find new treatments with less side effects. On the other hand, by dissecting the role of monoamine system in learning and decision making, we expect to build up a theoretical model of how monoamine control behavior.
1. Simmler LD#, Li Y#, Hadjas LC, Hiver A, Van Zessen R, Lüscher C* (2022). Dual action of ketamine confines addiction liability. Nature. 608(7922):368-373
2. Pascoli V#, Hiver A#, Li Y, Harada M, Esmaeili V, Lüscher C* (2022). Cell-type specific synaptic plasticity in dorsal striatum is associated with punishment-resistance compulsive-like cocaine self-administration in mice. Neuropsychopharmacology. In press
3. Li Y, Simmler LD, Van Zessen R, Flakowski J, Wan JX, Deng F, Li YL, Nautiyal KM, Pascoli V, Lüscher C* (2021). Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction. Science. 373(6560):1252-1256
4. Van Zessen R, Li Y, Marion-Poll L, Hulo N, Flakowski J, Lüscher C* (2021). Dynamic dichotomy of accumbal population activity underlies cocaine sensitization. eLife. 10:e66048
5. Li Y#, Li CY#, Xi W, Jin S, Wu ZH, Jiang P, Dong P, He XB, Xu FQ, Duan SM, Zhou YD, Li XM* (2019). Rostral and Caudal Ventral Tegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid Dependence. Neuron. 101(4):748-761