Faculty
Prof. Hong-ying Sha

Prof. Hong-ying Sha


Principal Investigator

Research Directions

1. Reprogramming human somatic cells into pluripotent stem cells by somatic cell nuclear transfer
2. Directed differentiation of embryonic stem cells into neural lineage cells

Contact  Information

Address: State Key Laboratory of Medical Neurobiology, Fudan University. Room 909, Zhidao Building, Fudan University, 130 Dong An Road,Shanghai, 200032, China
Tel:021-54237480  Email:shahongying@163.com

Professor Hongying Sha received her B.S. degree in Biology from East China Normal University in 1991 and M.S. degree in Cell Biology from Life Sciences Institute, East China Normal University in 2004. She obtained her Ph.D. degree in developmental biology from Life Sciences Institute, Tongji University in 2007. She had her postdoctoral training in neurosurgery of Huashan Hospital, Fudan University, majored in “Directed differentiation of embryonic stem cells into neural lineage cells” (2007-2009). Since she joined the faculty of National Key Laboratory of Medical Neurobiology, Fudan University in 2009. she has been focusing on the research of neurobiology, stem cells research and reproductive genetics. She invented a new technique of polar body genome transfer for preventing inherited mtDNA disease, which was published on CELL in 2014 and was selected as one of the “China’s top 10 scientific events” in 2014. She has received “Fudan University's Female Innovation Award” and “Excellent undergraduate tutor of Fudan University” for her achievements in research and teaching.

 

Enrollment Major
Neurobiology


Research Directions

  1. Reprogramming human somatic cells into pluripotent stem cells by somatic cell nuclear transfer

  2. Directed differentiation of embryonic stem cells into neural lineage cells


Selected Publications

  1. Tian Wang#, Hongying Sha#*,Dongmei Ji#, Helen L Zhang, Dawei Chen, Yunxia Cao, and Jianhong Zhu*. Polar Body Genome Transfer For Preventing the Transmission of Inherited Mitochondrial Diseases.Cell, 2014  Jun 19; 157(7): 1591-604

  2. Wang Tian, Shi Sanbao, Sha Hongying*. MicroRNAs in Regulation of Pluripotency and Somatic Cell Reprogramming: Small Molecule with Big Impact. RNA Biology, 2013 Aug 1; 10(8): 1255–1261.

  3. Hailiang Tang#, Hongying Sha#, Huaping Sun#, Xing Wu, Liqian Xie, Pu Wang, Chengshi Xu, Christian Larsen, Helen L. Zhang, Ye Gong, Ying Mao, Xiancheng Chen, Liangfu Zhou, Xiaoyuan Feng*, Jianhong Zhu*. Tracking iPSCs-derived Neural Stem Cells in CNS of Rats and Monkeys. Cell Reprogramming, 2013 Oct; 15(5): 435–442.

  4. X Wu#, H Sha#, R Sun, H Liu, Q Yuan, T Zhang, J Zhu, L Zhou, J HU*. N-terminal pro-B-type natriuretic peptide in patients with isolated traumatic brain injury: a prospective study. J Trauma. 2011 Oct;71(4):820-825.

  5. HY Sha#, JQ Chen, J Chen, PY Zhang, P Wang, LP Chen, GX Cheng, JH Zhu*. Fates of Donor and Recipient mitochondrial DNA during generation of interspecies-SCNT-derived human ES-like cells. Cloning and Stem Cells, 2009 Dec;11(4):497-507.

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