Prof. Shi-Jun Weng
Research Directions
Retinal structure, function and retinal remodeling in neurological diseases
Contact Information
Address: Institutes of Brain Science, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China
Tel：021-5423-7758 Email: sjweng@fudan.edu.cn
Shi-Jun Weng graduated from the Department of Biology, East China Normal University in 2000, and received his Ph.D. from the Institute of Neuroscience, Chinese Academy of Sciences in 2005. From 2007 to 2010, he worked as a postdoctoral associate in the Department of Neuroscience, Brown University, USA. He joined the Institute of Neurobiology/Institutes of Brain Science, Fudan University at 2011. His work has been funded by the Young Scientists Fund of the National Natural Science Foundation of China (NSFC), NSFC General Programs, and International Collaborative Research Fellowship Grant of the Association for Vision and Ophthalmology (ARVO). He participated in the writing/translation of a number of books such as Encyclopedia of China, From Neuron to Brain, and Methods in Molecular Biology. He has served as a reviewer for various international journals such as IOVS and Exp Eye Res.
Shi-Jun Weng performs basic and applied basic retinal researches at both in-vitro and in-vivo levels using multidisciplinary techniques, such as electrophysiology, optogenetics, chemoenetics and behavioral tests in combination with mouse ophthalmology disease models. The main research progress in recent years includes: the role of multiple retinal neural pathways controlling refractive development and myopia formation, cell-subtype-specific remodeling of intrinsically photosensitive retinal ganglion cells in diabetic retinopathy, structure and function of novel inhibitory circuits in the inner retina mediated by specific amacrine cells. The total citation of his work has exceeded 1000. For a detailed list of his papers, please see https://pubmed.ncbi.nlm.nih.gov/?term=+weng+shijun.
Enrollment Major
Neurobiology
Research Direction
Retinal structure, function and retinal remodeling in neurological diseases
Selected Publications
1. Wang G, Liu YF, Yang Z, Yu CX, Tong Q, Tang YL, Shao YQ, Wang LQ, Xu X, Cao H, Zhang YQ, Zhong YM, Weng SJ*, Yang XL* (2023). Short-term acute bright light exposure induces a prolonged anxiogenicc effect in mice via a retinal ipRGC-CeA circuit. Sci Adv. 9:eadf4651
2. Tang YL, Liu AL, Lv SS, Zhou ZR, Cao H*, Weng SJ*, Zhang YQ* (2022). Green light analgesia in mice is mediated by visual activation of enkephalinergic neurons in the ventrolateral geniculate nucleus. Sci Transl Med. 14:eabq6474
3. Liu AL, Liu YF, Wang G, Shao YQ, Yu CX, Yang Z, Zhou ZR, Han X, Gong X, Qian KW, Wang LQ, Ma YY, Zhong YM*, Weng SJ*, Yang XL* (2022). The role of ipRGCs in ocular growth and myopia development. Sci Adv. 8:eabm9027
4. Chen WY#, Han X#, Cui LJ, Yu CX, Sheng WL, Yu J, Yuan F, Zhong YM, Yang XL, Weng SJ* (2021). Cell-subtype-specific remodeling of intrinsically photosensitive retinal ganglion cells in streptozotocin-induced diabetic mice. Diabetes. 70:1157-1169
5. Zhou W, Wang LQ, Shao YQ, Han X, Yu CX, Yuan F, Wang X, Weng SJ*, Zhong YM*, Yang XL* (2021). Orexin-A intensifies mouse pupillary light response by modulating intrinsically photosensitive retinal ganglion cells. J Neurosci. 41:2566-2580
