A/Prof. Mei Yu

Research Direction
Molecular mechanisms of neurodegenerative diseases
Contact Information
Address: Institutes of Brain Science, Fudan University, 131 Dong An Rd, Shanghai China 200032

Dr. Mei Yu studied at the State Key Laboratory of Medical Neurobiology, Fudan University from 2005 to 2008 for a Ph.D. After graduating in 2008, she worked in Fudan University and engaged in basic research on Parkinson's disease. From March 2011 to November 2012, she worked as a postdoc in the Department of Neurology, University of Pittsburgh Medical Center, USA. Since December 2015, she has been employed as an associate professor of Shanghai Medical College/ Institutes of Brain Science, Fudan University.

Her research has focused on the molecular mechanism of Parkinson's disease and Alzheimer's disease. Her major research results in recent years include: NRSF (neuron-restricted silencing factor) can affect the pathology and behavior in the mouse models of Parkinson's disease by regulating neuroinflammation induced by microglia and astrocyte activation, neurogenesis, and epigenetics, which suggests that NRSF might play an important role in the pathological mechanism of Parkinson's disease; MiR-29b/c, NF-κB c-Rel and RESP18 are also involved in Parkinson's disease. These research results have been published in SCI journals such as: Redox Biology, Neurobiology of Aging, Neuropharmacology, etc.

Selected Publications

1. Wang ZS, Dong HT, Wang JH, Huang YL, Zhang XS, Tang YL, Li Q, Liu ZL, Ma YY, Tong JB, Huang L, Fei J, Yu M*, Wang J*, Huang F*(2020). Pro-survival and anti-inflammatory roles of NF-kappa B c-Rel in the Parkinson's disease models. Redox Biol. 30: 101427

2. Huang D, Wang Z, Tong J, Wang M, Wang J, Xu J, Bai X, Li H, Huang Y, Wu Y, Ma Y, Yu M*,  Huang F*(2018). Long-term changes in the nigrostriatal pathway in the MPTP mouse model of Parkinson’s disease. Neuroscience. 369:303-313

3.Liu J, Huang D, Xu J, Tong J, Wang Z, Huang L, Yang Y, Bai X, Wang P, Suo H, Ma Y, Yu M*, Fei J*, Huang F* (2015).Tiagabine protects dopaminergic neurons against neurotoxins by inhibiting microglial activation. Sci Rep-UK. 5:15720

4. Suo HY, Wang P, Tong JB, Cai L, Liu J, Huang DP, Huang L, Wang ZS, Huang YF, Xu J, Ma YY, Yu M*, Fei J*, Huang F*(2015). NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson's disease. Neuropharmacology. 99:67-78

5. Yu M, Suo HY, Liu M, Cai L, Liu J, Huang YF, Xu J, Wang YC, Zhu CQ, Fei J*, Huang F* (2013). NRSF/REST neuronal  deficient mice are more vulnerable to the neurotoxin MPTP. Neurobiol Aging. 34(3):916-927

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