A/Prof. Jing-Chun Guo

Research Direction
Molecular mechanisms of metabolic dysfunction-related neurodegeneration and neuroprotection
Contact Information
Address: Institutes of Brain Science, Fudan University, 131 Dong An Rd, Shanghai China 200032
Email: jingchunguo@shmu.edu.cn

Dr. Jing-Chun Guo received her B.S. degree in Biochemistry from Fudan University in 1992 and Ph.D. degree in Integrative Discipline of Chinese and Western medicine from Fudan University in 2005. She joined Shanghai Medical University (presently Fudan University Medical Center) as a lecture in 1992 and currently an associate professor in the Institutes of Brain Science, Fudan University. Her research has focused on the molecular mechanisms of metabolic dysfunction-related neurodegeneration and signal transduction of cellular senescence in the brain. Dr. Guo has been responsible for 4 natural science foundation projects and published dozens of papers in international journals.

Enrollment Major

Neurobiology

Selected Publications

1. Xue WJ, He CF, Zhou RY, Xu XD, Xiang LX, Wang JT, Wang XR, Zhou HG*, Guo JC*(2022). High glucose and palmitic acid induces neuronal senescence by NRSF/REST elevation and the subsequent mTOR-related autophagy suppression. Mol Brain. 15(1):61
2. He CF, Xue WJ, Xu XD, Wang JT, Wang XR, Feng Y, Zhou HG*, Guo JC*(2022). Knockdown of NRSF Alleviates Ischemic Brain Injury and Microvasculature Defects in Diabetic MCAO Mice. Front Neurol. 13: 869220
3. Wang YM, Mi SL, Jin H, Guo QL, Yu ZY, Wang JT, Zhang XM, Zhang Q, Wang NN, Huang YY*, Zhou HG*, Guo JC*(2021). 9-PAHSA Improves Cardiovascular Complications by Promoting Autophagic Flux and Reducing Myocardial Hypertrophy in Db/Db Mice. Front Pharmacol. 12: 754387
4. Wang JT, Yu ZY, Tao YH, Liu YC, Wang YM, Guo QL, Xue JZ, Wen XH, Zhang Q, Xu XD, He CF, Xue WJ, Guo JC*, Zhou HG*(2021). A novel palmitic acid hydroxy stearic acid (5-PAHSA) plays a neuroprotective role by inhibiting phosphorylation of the m-TOR-ULK1 pathway and regulating autophagy. CNS Neurosci Ther. 27(4):484-496
5. Xu XD, Wen XH, He CF, Yu ZY, Wang JT, Zhou HG*, Guo JC*(2020). Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain. Biochem Bioph Res Co. 527(3): 785-790