A/Prof. Chang-You Jiang
The molecular and neural circuit mechanisms of drug addiction
Address: 138 Yixueyuan Road, Institutes of Brain Science, Fudan University, Shanghai China 200032
Changyou Jiang is currently a Young associated professor at the Institutes of Brain Science (IOBS), Fudan University. Dr. Changyou Jiang received B.S. degree in Pharmacy from Shandong University in 2014 and Ph.D. degree in Pharmacology from Fudan University in 2019. From 2019 to 2021, he worked as a postdoc in the basic science at Fudan University, under supervision of academician of Chinese Academy of Sciences, Dr. Lan Ma. In November of 2021, Dr. Jiang joined the institute of brain science at Fudan University. His work has been published on Molecular Psychiatry, Translational Psychiatry, and other peer-reviewed scientific journals.
The mechanism of drug addiction involves interactions between memory, emotion and motivation circuits. The functional unit of brain information output and memory engram storage is the neuronal ensembles which response to specific time and space. So the new research suggests that the maladaptation in the function and circuit of specific neuronal ensembles is closely associated with addiction. Drug addiction has both positive and negative reinforcement effect. The rebound between positive and negative reinforcement usually leads to the drug abuse and relapse. Therefore, our research work focus on the positive and negative reinforcement induced by addicted drugs. Combing with neuronal ensemble labeling systems, in-vivo fiber photometry, electrophysiology, optogenetics, chemogenetics, anterograde and retrograde virus, RNA sequencing and the mouse addiction behavior models, we are trying to explore the remodeling and signal transduction changes of addiction-related neuronal ensembles during the process of addiction, as well as their roles in regulation of reinforcements, thus to explore anti-relapse drugs.
1. Jiang CY, Yang X, He GH, Wang F, Wang ZL, Xu WD, Mao Y, Ma L*, Wang FF* (2021). CRHCeA→VTA inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal. Molecular Psychiatry. 26(11): 6170-6186
2. Jiang CY, Wang XY, Le QM, Liu PP, Liu C, Wang ZL, He GH, Zheng P, Wang FF*, Ma L*(2021). Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward. Molecular Psychiatry. 26(4): 1178–1193. (ESI Neuroscience & Behavior, Highly cited paper 1%)
3. Wang XY, Yu M, Ma L, Wang FF, Jiang CY* (2019). Corticotrophin-releasing hormone neurons in the central amygdala mediate morphine withdrawal-induced negative emotions，Sheng li xue bao. 71(06): 824-832.
4. Shen MJ, Jiang CY, Liu PP, Wang FF*, Ma L* (2016). Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward. Translational Psychiatry. 6(12): e972.
5. Wang L#, Shen MJ#, Jiang CY#, Ma L*, Wang FF* (2016). Parvalbumin interneurons of central amygdala regulate the negative affective states and the expression of corticotrophin-releasing hormone during morphine withdrawal. International Journal of Neuropsychopharmacolpgy. 19(11): pyw060.