A/Prof. Chang-You Jiang
Research Direction
The molecular and neural circuit mechanisms of drug addiction
Contact Information
Address: 138 Yixueyuan Road, Institutes of Brain Science, Fudan University, Shanghai China 200032
Email: jiangcy@fudan.edu.cn
Changyou Jiang received his Bachelor of Science degree from Shandong University in 2014 and his Ph.D. degree in Pharmacology from Fudan University in 2019. He then proceeded to complete his postdoctoral training at the Institute of Brain Science of Fudan University from 2019 to 2021. In November 2021, he commenced his tenure at the Institute of Brain Science/Ministry of Education's Center for Frontier Brain Science at Fudan University. He has been bestowed with a number of academic titles, including Shanghai Young Science and Technology Rising-star, Shanghai Chengguang Scholar, Shanghai Super Postdoc, and Excellent Postdoc of Fudan University.
His primary research interest is the neuronal ensemble mechanism of drug addiction. He has published several notable findings in leading academic journals, including the Journal of Clinical Investigation (2024), Molecular Psychiatry (2019, 2021, 2023), and other peer-reviewed publications as a corresponding author or first author (including co-authors).
The mechanism of drug addiction involves interactions between memory, emotion and motivation circuits. The functional unit of brain information output and memory engram storage is the neuronal ensembles which response to specific time and space. So the new research suggests that the maladaptation in the function and circuit of specific neuronal ensembles is closely associated with addiction. Drug addiction has both positive and negative reinforcement effect. The rebound between positive and negative reinforcement usually leads to the drug abuse and relapse. Therefore, our research work focus on the positive and negative reinforcement induced by addicted drugs. Combing with neuronal ensemble labeling systems, in-vivo fiber photometry, electrophysiology, optogenetics, chemogenetics, anterograde and retrograde virus, RNA sequencing and the mouse addiction behavior models, we are trying to explore the remodeling and signal transduction changes of addiction-related neuronal ensembles during the process of addiction, as well as their roles in regulation of reinforcements, thus to explore anti-relapse drugs.
Selected Publications
1. Jiang CY*, Huang H, Yang X, Le QM, Liu X, Ma L*, Wang FF*(2024). Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiatewithdrawal. The Journal of clinical investigation. 134(5): e171995
2. Jiang CY, Yang X, He GH, Wang F, Wang ZL, Xu WD, Mao Y, Ma L*, Wang FF* (2021). CRHCeA→VTA inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal. Molecular Psychiatry. 26(11): 6170-6186
3. Jiang CY, Wang XY, Le QM, Liu PP, Liu C, Wang ZL, He GH, Zheng P, Wang FF*, Ma L*(2021). Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward. Molecular Psychiatry. 26(4): 1178–1193. (ESI Neuroscience & Behavior前1%高被引论文)
4. He GH#, Huai ZQ#, Jiang CY#, Huang B, Tian Z, Le QM, Fan GY, Li HB, Wang FF, Ma L*, Liu X* (2023). Persistent increase of accumbens cocaine ensemble excitability induced by IRK downregulation after withdrawal mediates the incubation of cocaine craving. Molecular Psychiatry. 28(1): 448-462
5. Shen MJ, Jiang CY, Liu PP, Wang FF*, Ma L* (2016). Mesolimbic leptin signaling negatively regulates cocaine-conditioned reward. Translational Psychiatry. 6(12): e972
