A/Prof. Wei Li

Research Direction
New mechanism of learning and memory regulation; New mechanism of emotional memory regulation
Contact Information
Address: Room B5-012, Institute of Brain Science, Fudan University, 131 Dongan Road, Shanghai, China, 200032
Email: leewei@fudan.edu.cn

Dr. Wei Li received her double Bachelors of biotechnology and computer technology in Zhejiang University. Dr. Wei Li received her Ph.D. of Neurology at School of medicine in Tsinghua University. She obtained the post-doctoral training at department of bioengineering in Tsinghua University. She once served as an application expert in Leica pathology Shanghai R & D center. She joined the Institutes of Brain Science at Fudan University in 2015.

Research Work

1)New regulation mechanism of emotional memory： The integration model of fear memory between mice and humans was established by using mathematical modeling, behavior and psychology, and further verified at the molecular and clinic level. A simple mathematical method with less trauma, low cost and theoretical support was established to predict individual fear memory intensity and fear spontaneous recovery.

2)New learning and memory regulation mechanism：Molecular and cellular biology, optogenetics, electrophysiology, behavior, pharmacology, genetics and other means are used to deeply study the new mechanism of learning and memory, and reveal the new targets of drugs related to neurodegenerative diseases.

Selected Publications

1. Gao Y#, Li W#, Sui B, Abumaria N*(2020). Individual differences in learning rate and fear response predict fear memory and recovery in mice and human subjects. Neurosci Bull. 36(7):815-820

2.Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, … Kawabe H*, Craig AM*(2020). Optimizing nervous system-specific gene targeting with cre driver lines: prevalence of germline recombination and influencing factors. Neuron.106(1): 37-65

3. Liu YQ, Chen C, Liu YL, Li W, Wang ZH, Sun QF, Zhou H, Chen XJ, Yu YC, Wang Y, Abumaria N*(2018). TRPM7 is required for normal synapse density, learning, and memory at different developmental stages. Cell Rep. 23(12): 3480-3491(Cover Story)

4. Li CQ, Cao FF, Li SL, Huang SL, Li W*, Abumaria N*(2018). Profiling and co-expression network analysis of learned helplessness regulated mRNAs and lncRNAs in the mouse hippocampus. Front Mol Neurosci. 10: 454

5. Li W, Yu J, Liu Y, Huang X, Abumaria N, Zhu Y, Huang X, Xiong W, Ren C, Liu XG, Chui D, Liu G*(2014). Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model. Mol Brain. 7:65