Prof. Bin Lai
Drug addiction-related pathological memory
Address: ：Room B5-027, Research Building No. 2,138 Yixueyuan Road, Institutes of Brain Science, Fudan University, Shanghai China 200032
Dr. Bin Lai received his Ph.D. degree in fudan university in 2004. From 2006 to 2007, he obtained the postdoctoral training at Buck institute in USA. He joined the State Key Laboratory of Medical Neurobiology at Fudan University since 2004. His work was published on several important journals in neuroscience including Science Advances、Cell Reports、Experimental Neurology and Addiction Biology.
Long-term use of addictive substances can lead to severe physical dependence and painful withdrawal symptoms, which facilitates the formation of persistent pathological memories. This is an important reason for the abuse of addictive substances. Complex neural circuits in the brain are the basis of memory formation, and the application of addictive substances can change the plasticity of them, thus promoting the formation and storage of addiction-related pathological memories. Our lab mainly explores the neural circuits and molecular mechanism of in addiction related pathological memory formation.
1. Shao Da*, Cao ZX, Fu YL, Yang H, Gao PY, Zheng P*, Lai B*(2021). Projection from the basolateral amygdala to the anterior cingulate cortex facilitates the consolidation of long-term withdrawal memory.Addict Biol. e13048
2. Yu LF, Chu CS, Yuan Y, Guo XL, Lei C, Sheng H, Yang L, Cui DY, Lai B*, Zheng P*(2021). Activity in projection neurons from prelimbic cortex to the PVT is necessary for retrieval of morphine withdrawal memory. Cell Rep. 35(1): 108958
3. Ma QQ, Fu YL, Cao ZX, Shao D, Song JJ, Sheng H, Yang L, Cui DY, Chen M, Zhao F, Luo MH, Lai B*, Zheng P*(2020). A conditioning-strengthened circuit from CA1 of dorsal hippocampus to basolateral amygdala participates in morphine-withdrawal memory retrieval. Front Neurosci-Switz. 14: 646
4. Song JJ, Shao D, Guo XL, Zhao YF, Cui DY, Ma QQ, Sheng H, Ma L, Lai B*, Chen M*, Zheng P*(2019). Crucial role of feedback signals from prelimbic cortex to basolateral amygdala in the retrieval of morphine withdrawal memory.Sci Adv. 5(2): eaat3210
5. Chen M, Shao D, Fu YL, Ma QQ, Chen M, Cui DY, Song JJ, Sheng H, Yang L, Dong Y, Lai B*, Zheng P*(2019). Key determinants for morphine withdrawal conditioned context-induced increase in Arc expression in anterior cingulate cortex and withdrawal memory retrieval. Exp Neurol. 311: 234-246